NewsLetter

Valerio-Santiago, Mauricio1; Garcia, Consuelo1; Aguirre, Belén1; Subirós, Ramón1; Soley, Albert1; Mola, Gemma1; Delgado, Raquel1
1Lipotec SAU Isaac Peral 17 (Pol. Industrial Camí Ral), 08850 Gavà (Barcelona) Spain

INTRODUCTION

In an era marked by advancing technology within an evolving landscape, the burgeoning demand for performance-driven skin care technology tools and devices persists. Convenient, at-home microcurrent devices have seen a surge in popularity, however, the steep cost and apprehensions regarding safety issues such as potential skin damage are compelling consumers to seek more accessible topic alternatives that replicate comparable effects in an efficient and gentle manner. Collectively, microcurrents synergistically counteract facial sagginess by orchestrating a mechanism involved MBNL1, an RNA binding protein exhibiting heightened contraction ability. Drawing inspiration from the strides in at-home devices, Lubrizol Life Science has pioneered the development of a novel tetrapeptide, Uplevity™ e-Lift peptide, designed to emulate the skin benefits offered by microcurrent devices, specifically targeting upper facial lifting effects, validated through in vitro and in vivo studies.

METHODS AND RESULTS

The peptide, INCI: Water (Aqua), Tetrapeptide-1, Caprylyl Glycol, is a naturally-derived eco-friendly peptide produced following the principles of green chemistry. This tetrapeptide brings minimal environmental impact as a result of its high natural origin content (99.5% in the commercial solution according to ISO16128) and readily biodegradable status according to OECD guidelines (98% degradation in 28 days).

Mimicking the skin benefits of microcurrents in the dermal layer

We firstly demonstrated that the peptide was able to boost the levels of MBNL1, which is known to promote the transdifferentiation of fibroblasts to myofibroblasts.
As shown in Figure 1, treatment with the peptide increased MBNL1 protein amount in fibroblasts in a dose response manner and in a similar way to microcurrent stimulation.

To further confirm the microcurrent-like effect of the novel peptide, we evaluated the ability of the peptide to induce collagen contraction. The novel peptide induced collagen contraction by 37.5% with respect to the control condition.

 

Overall, the novel peptide has demonstrated to activate the molecular targets and the biological functions that take place after micro current stimulation at the dermis and muscle layers, which may help to provide an enhanced skin lifting and firming properties.

A “triorbital” skin lifting effect, comparable to using a microcurrent device.

A clinical test was carried out on 36 Caucasian female and male volunteers aged between 42 and 65 years old. These volunteers applied a cream containing 2% of the novel peptide solution or a placebo cream on the half upper face, twice day for 28 days, following a hemi-face design. A second group of 10 volunteers used a commercial microcurrent device, once a day 5 days a week, and applied a placebo cream, twice a day for 28 days.
Furthermore, the eyebrow lift efficacy was very similar to the group using the microcurrent device.

 

CONCLUSIONS

The novel peptide from Lubrizol Life Science emerges as an innovative topical active ingredient which confers a rejuvenated lifting and anti-wrinkle effect, inspired by microcurrents devices. In vitro, it has been demonstrated to activate the same biological functions as microcurrent stimulation: improving dermal contraction and muscle tone. Clinically, the novel peptide confers an upper facial lifting effect in combination with anti-wrinkle benefits after 28 days and 7 days of product treatment, respectively. It has been shown to enhance eyebrow, eyelid, crow´s feet and upper cheek lifting leading to a “triorbital” skin lifting effect. Furthermore, the peptide reduces the severity of the visibility of wrinkles in the crow´s feet region and underneath the eye. In conclusion, novel peptide is an ideal solution for an overall upper face lifting appearance, inspired by the skin benefits provided by at-home microcurrents devices and showing a similar rejuvenating efficacy.


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