Organiser
A multifaceted, broad-spectrum complex molecule for personal and home care. SALIBACT our globally patented technology, began as a broad-spectrum preservative, but as time went on, the combination of undecylenic acid and chlorhexidine complexation yielded additional benefits such as anti-acne, anti-dandruff, equivalent performance to triclosan in dental care, and strong anti-bacterial properties. Additionally, it’s partial bio-degradability revealed sustainability benefits.
Mode of action:
Like other Chlorhexidine salts, Salibact also kills microorganisms by disrupting their cell membrane.
The Chlorhexidine moiety of Salibact is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death. The Undecylenic acid moiety deactivates the enzymes and metabolites in the lipid membrane of Mold/fungi that regulates homeostasis. This arrests cell growth and results in stress response failure causing cell death.
Minimum Inhibitory Concentration: Chlorhexidine Undecylenate was tested for its activity against bacteria (both Gram +ve and Gram -ve), yeast, and fungi. The resulting MIC against these microbes is listed below
Recommendations: Salibact at 0.1% concentration can be used as a preservative and as a specialised active. To leverage its anti-dandruff and anti-acne properties, it can be used up to a maximum of 0.3%
Solubility:
Salibact is hydrophobically modified so it is water insoluble. Therefore, this has to be pre dissolved into propylene glycol or PEG or ester oil and then added into an emulsion at the end of the process and into surfactant base system products.
Versatile Use Cases:
The distinctive hydrophobic properties prevent it from being "easily washed off." In particular, it enhances COSERVATION in shampoos by leveraging its hydrophobic properties, enabling better deposition on the scalp. It achieves the same efficacy at 0.3% as traditional anti-dandruff agents do at 2.0%. Additionally, this makes it effective at lower dosages for leave-on products. Traditional anti-dandruff shampoos are loaded with a minimum of 2% of actives like climbazole, PO and ZPTO. Moreover, the silicone concentrations in these products (3-5%) cause foam killing. To counteract this effect, higher dosages of surfactant actives are added. This increase however, raises the probability of scalp irritation. Salibact’s ability to be effective at a low dosage of 0.3% without having any negative impact on foam killing makes it a significantly better ingredient for formulation. It addresses the challenges formulators face when trying to stabilize high dosages of anti-dandruff actives combined with suspending agents.
Salibact’s ability to be effective at low dosages extends to anti-acne products as well. While traditional ingredients such as Salicylic Acid are used at 2%, Salibact achieves the same efficacy at 0.3%. The product control excess oil on acne-prone skin and inhibits the activity of acne causing bacteria.
The molecules showcase its versatility at higher pH’s too. (need some more information here) This is a very versatile molecule that functions even at higher pH, where the majority of the active ingredients begin to oxidize. It claims 99.9% bacterial reduction in a specified period of time.
Lastly, the application of Salibact in oral care is quite fascinating. With a 0.1% dosage, we were able to achieve equivalent plaque and gingivitus reduction when compared to 0.3% Triclosan.